Genes And Cancer RiskInherited mutations in these genes confer a very high cancer risk. Red type indicates cancer most often associated with mutation in the listed gene. | |||
| GENE | TUMOR TYPE | GENE CLASS | |
|---|---|---|---|
| BREAST CANCER | BRCA1 | Breast, ovary | Tumor suppressor |
| BRCA2 | Breast (both sexes) | Tumor suppressor | |
| p53 | Breast, sarcoma Tumor | suppressor | |
| COLON CANCER | MSH2 | Colon, endometrium, other | Mismatch repair |
| MLH1 | Colon, endometrium, other | Mismatch repair | |
| PMS1,2 | Colon, other | Mismatch repair | |
| APC | Colon | Tumor suppressor | |
| MELANOMA | MTS1 (CDKN2) | Skin, pancreas | Tumor suppressor |
| CDK4 | Skin | Tumor suppressor | |
| NEUROENDOCRINE CANCER | NF-1 | Brain, other | Tumor suppressor |
| NF-2 | Brain, other | Tumor suppressor | |
| RET | Thyroid, other | Oncogene | |
| KIDNEY CANCER | WT1 | Wilms' tumor | Tumor suppressor |
| VHL | Kidney, other | Tumor suppressor | |
| RETINOBLASTOMA | RB | Retinoblastoma, sarcoma, other | Tumor suppressor |