REPLICATION AND TRANSCRIPTIONAL STRATEGIES OF DNA VIRUSES
FamilyGenomeReplicationTranscriptaseRNA transcripts/protein
Papovaviridae Adenoviridae HerpesviridaedsDNAConventional DNA replication using cellular enzymescellular DNA-dependent RNA polymerase IIspliced RNA transcripts via polycistronic mRNA; viral protein
PoxviridaedsDNAConventional DNA replication (in the cytoplasm)virion associated DNA-dependent RNA polymerasemonocistronic mRNA; viral protein
ParvoviridaessDNAcellular DNA polymerase for the synthesis of dsDNAcellular DNA-dependent RNA polymerase IIspliced mRNA; viral protein
Hepadnaviridaess/dsDNAviral reverse transcriptase produces (-) strand DNA* from (+) strand RNA;
(-) strand DNA serves as a template for dsDNA via viral DNA polymerase		cellular DNA-dependent RNA polymerase II produces subgenomic and genomic mRNA [(+) strand RNA)];
genomic (+) strand RNA serves as a template for reverse transcription		(+) strand subgenomic RNA as mRNA; viral protein
*(+)ssRNA = positive or sense single stranded RNA; (-)ssRNA = negative or antisense ssRNA; (ds)DNA = double stranded DNA with both positive/negative strands, i.e., complementary nucleotide sequences. By convevtion, the noncoding strand of DNA is designated as the (+) or sense strand, while the coding (transcribed) strand is designated as the (-) or antisense strand. Thus, (+) strand RNA can serve as mRNA for protein synthesis and is similar in sequence to the noncoding (+) strand of DNA.